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Medical-grade PLGA microspheres are widely used in various biomedical applications due to their biocompatibility, biodegradability, and ability to provide controlled and sustained release of therapeutic agents. Below are some of their key applications:
1. Drug Delivery Systems
Sustained-Release Injectables: PLGA microspheres are used to deliver drugs, such as hormones, analgesics, and chemotherapeutics, over an extended period (e.g., Lupron Depot for prostate cancer).
Targeted Delivery: They enable localized delivery of drugs to specific tissues or organs, reducing systemic side effects and improving efficacy.
2. Tissue Engineering
PLGA microspheres are incorporated into scaffolds or directly injected to deliver that promote tissue regeneration (e.g., bone, cartilage, and skin).
Cell Delivery Support: They can serve as carriers for cells in regenerative medicine applications.
3. Ophthalmology
Intraocular Drug Delivery: PLGA microspheres are used for the sustained release of drugs in treating eye diseases such as glaucoma, diabetic retinopathy, or macular degeneration.
4. Dermatology and Aesthetics
Controlled Release of Active Ingredients: Used in skin regeneration and cosmetic treatments, such as delivering peptides, vitamins, or other actives for skin repair or anti-aging.
| Description |
Poly(lactic-co-glycolic acid) is a copolymer which is used in a host of Food and Drug Administration (FDA) approved therapeutic devices, owing to its biodegradability and biocompatibility. PLGA are currently widely used in many fields, such as bone nail; coatings; lifting thread; absorbable suture; ophthalmic implant; microspheres, gel for drug delivery etc. |
| Physical-chemical properties |
Chemical name Poly(L-lactide-co-glycolide)
CAS Registry number 30846-39-0 |
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