| Customization: | Available |
|---|---|
| CAS No.: | 30846-39-0 |
| Formula: | (C6h8o4*C4h4o4)N |
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Poly(lactic-co-glycolic acid) is a copolymer which is used in a host of Food and Drug Administration approved therapeutic devices, owing to its biodegradability and biocompatibility. PLGA are currently widely used in many fields, such as bone nail; coatings; lifting thread; absorbable suture; microspheres, gel for drug delivery etc.
PLGA5050:
•Composition: This copolymer has a 50:50 ratio of lactide to glycolide monomers.
•Degradation: Due to its high glycolide content, PLGA5050 degrades relatively quickly compared to other ratios. The higher glycolide proportion accelerates hydrolysis, leading to faster erosion times.
•Mechanical Strength: It tends to have lower mechanical strength because of its faster degradation rate. This can limit its use in applications requiring long-term structural integrity.
•Applications: PLGA5050 is often used in applications where rapid degradation is desired, such as short-term drug delivery systems, temporary implants, or scaffolds for tissue engineering that need to be replaced by natural tissue rapidly.
PLGA7525:
•Composition: With a 75:25 ratio, this copolymer has a higher percentage of lactide, contributing to its distinct properties.
•Degradation: PLGA7525 degrades more slowly than PLGA5050, providing a more controlled release profile over a longer period. The higher lactide content results in a more crystalline structure, slowing down the degradation process.
•Mechanical Strength: It possesses greater mechanical strength and durability due to its higher lactide content, making it suitable for applications that require support or longer-term implantation.
•Applications: Its properties make it ideal for extended-release drug delivery systems, implants that need to maintain their structure for a moderate duration, and as a scaffold material in tissue engineering where a balance between degradation and mechanical support is crucial.
| Description | Poly(lactic-co-glycolic acid) is a copolymer that is used in a host of Food and Drug Administration-approved therapeutic devices, owing to its biodegradability and biocompatibility. PLGA is currently widely used in many fields, such as bone nails; coatings; lifting thread; absorbable sutures; microspheres, gel for drug delivery, etc. | ||||||
| Physical-chemical properties | Molecular formula (C6H8O4*C4H4O4)n Chemical name Poly(L-lactide-co-glycolide) CAS Registry number 30846-39-0 |
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| Parameter |
Item | Test Method | Specification | ||||
| Appearance | Visual | White, pale yellow powder or floccule | |||||
| Inherent viscosity | Ubbelohde viscometer | 0.20-2.50 dl/g |
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| Residual Solvent | Gas Chromatography | ≤0.5% | |||||
| Heavy Metal Sulphated Ash |
Chemical Reagent Sulfuric Acid |
≤10 ppm ≤0.1% |
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| For each batch a certificate of analysis is provided, showing the analytical data determined in our quality control laboratory. Additional analytical data can be made upon request. | |||||||
| Packaging | 100g/500g/1Kg per aluminum foil bag | ||||||
| Recommend storage | Stored in a cool and dry place without sunlight, a refrigerator is recommended. Temperatures (2-8°C) Notice: PLGA with intrinsic viscosity below 0.3 is powdered and will melt at 18-22 °C. |
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| Shelf life | When stored in the original packaging at low temperatures (2-8°C), PLGA keeps its initial properties for at least two years. |
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| Product catalogue | Model | L-LA/GA Ratio |
IV | L-LA/GA Proportional Range |
IV Range dl/g |
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| PLG85-03 | 85/15 | 0.3 | 82/18-88/12 | 0.20-0.40 | |||
| PLG85-05 | 85/15 | 0.5 | 82/18-88/12 | 0.40-0.70 | |||
| PLG85-08 | 85/15 | 0.8 | 82/18-88/12 | 0.70-1.00 | |||
| PLG85-12 | 85/15 | 1.2 | 82/18-88/12 | 1.00-1.40 | |||
| PLG85-16 | 85/15 | 1.6 | 82/18-88/12 | 1.40-1.80 | |||
| PLG85-20 | 85/15 | 2.0 | 82/18-88/12 | 1.80-2.50 | |||
| PLG75-03 | 75/25 | 0.3 | 72/28-78/22 | 0.20-0.40 | |||
| PLG75-05 | 75/25 | 0.5 | 72/28-78/22 | 0.40-0.70 | |||
| PLG75-08 | 75/25 | 0.8 | 72/28-78/22 | 0.70-1.00 | |||
| PLG75-12 | 75/25 | 1.2 | 72/28-78/22 | 1.00-1.40 | |||
| PLG75-16 | 75/25 | 1.6 | 72/28-78/22 | 1.40-1.80 | |||
| PLG75-20 | 75/25 | 2.0 | 72/28-78/22 | 1.80-2.50 | |||
| PLG50-03 | 50/50 | 0.3 | 47/53-53/47 | 0.20-0.40 | |||
We offer medical-grade materials:
CAS: 33135-50-1, Poly l-lactic acid(PLLA), PLLA microspheres,
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